https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32277-3/fulltext Authors: Alastair Heffernan, Graham S Cooke, Shevanthi Nayagam, Mark Thursz, Timothy B Hallett Summary Background The revolution in hepatitis C virus (HCV) treatment through the development of direct-acting antivirals (DAAs) has generated international interest in the global elimination of the disease as a public health threat. In 2017, this led WHO to establish elimination […]
Virlogeux et al. BMC Medicine (2017) 15:217, DOI 10.1186/s12916-017-0979-1 BACKGROUND: HCV treatment uptake has drastically increased in HIV-HCV coinfected patients in France since directacting antiviral (DAA) treatment approval, resulting in HCV cure in 63% of all HIV-HCV patients by the end of 2015. We investigated the impact of scaling-up DAA on HCV prevalence in the […]
The burden of transmitted multi-drug resistance among epidemics of tuberculosis A transmission model.pdf A dynamic transmission model of multi-drug resistance tuberculosis (MDR-TB) epidemic was constructed with the inclusion of transmission-related and treatment-related acquisition of resistance. This modelling study showed that most of the incident MDR-TB cases are more likely from transmission than treatment-related acquisition of […]